Send to

Choose Destination
Int J Mol Cell Med. 2016 Winter;5(1):49-56.

Orosomucoid-1 Expression in Ameloblastoma Variants.

Author information

Laboratorio de Investigación en Odontología, ALMARAZ/UBIMED, FES Iztacala, UNAM. State of Mexico, Mexico.
Molecular Pathology, Universidad de la República (UDELAR), Montevideo, Uruguay.
Department of Infectomics and Molecular Pathogenesis, CINVESTAV-IPN, México, D.F, México.
Maxillofacial Surgery Department. Hospital Juárez de México, México D.F, México.
Instituto Nacional de Pediatría, México D.F, México.
Biochemistry, Microbiology and Pathology Laboratory, Faculty of Stomatology, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico.
Health Care Department, Universidad Autónoma Metropolitana, Xochimilco, UAM, México City, Mexico.
Department Research, School of Dentistry, Universidad Juárez del Estado de Durango, México.


Odontogenic tumors constitute a group of heterogeneous lesions of benign and malignant neoplasms with variable aggressiveness. Ameloblastomas are a group of benign but locally invasive neoplasms that occur in the jaws and are derived from epithelial elements of the tooth-forming apparatus. We previously described orosomucoid-1 protein expression in odontogenic myxomas. However, whether orosomucoid-1 is expressed in other odontogenic tumors remains unknown. Since orosomucoid-1 belongs to a group of acute-phase proteins and has many functions in health and disease, we identified and analyzed orosomucoid-1 expression in ameloblastoma variants and ameloblastic carcinoma using western blot and immunohistochemical techniques. Thirty cases of ameloblastoma were analyzed for orsomucoid-1; five specimens were fresh for western blot study (four benign ameloblastomas and one ameloblastic carcinoma), and 25 cases of benign ameloblastoma for immunohistochemical assays. Orosomucoid-1 was widely expressed in each tumor variant analyzed in this study, and differential orosomucoid-1 expression was observed between benign and malignant tumor. Orosomucoid-1 may play an important role in the behavior of ameloblastomas and influence the biology and development of the variants of this tumor.


Orosomucoid-1; ameloblastic carcinoma; ameloblastoma; odontogenic tumors


Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center