Send to

Choose Destination
Springerplus. 2016 Jul 1;5(1):952. doi: 10.1186/s40064-016-2402-3. eCollection 2016.

Prevention of intraocular pressure elevation with oleuropein rich diet in rabbits, during the general anaesthesia.

Author information

Department of Anesthesiology and Reanimation, Medical Faculty of Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
Department of Ophthalmology, Medical Faculty of Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
Department of Food Engineering, Engineering Faculty of Çanakkale Onsekiz Mart University, Çanakkale, Turkey.



Oleuropein is known to have anti-oxidant and anti-inflammatory effects. An important aim of anesthetic management in ocular surgery is to keep the intraocular pressure under control. Studies have researched a variety of prophylactic materials used to prevent increases in intraocular pressure. We aimed to research the effects of oleuropein on intraocular pressure (IOP) during general anaesthesia.


Fourteen New Zealand rabbits were randomly divided into two groups of seven. The rabbits in Group O were given olive leaf extract (OLE) equivalent to a daily dose of 20 mg/kg oleuropein for 15 days. HPLC method used for oleuropein standardization. For anaesthesia induction 1 mg/kg rocuronium was given and after muscle relaxation all animals had a V-gel Rabbit inserted. Anesthetic maintenance was provided by 1 MAC isoflurane. Twenty minutes after rabbits were given 10 mg/kg ketamine, basal IOP values were measured. After the V-gel rabbit was inserted, in the 5th, 10th, 20th, 25th and 30th minutes measurements were repeated.


IOP data variation of OLE group was compared with control group and the measured levels were lower in Group O during the anaesthesia. IOP was 33.8 ± 4 mmHg in Group C and 24.1 ± 8 mmHg in Group O in 25th minute and the difference between the two groups was statistically significant at this time.


We observed that consumption of prophylactic OLE had a reducing effect on IOP in the period before waking in anaesthesia. We believe it is necessary to investigate the effects of OLE on IOP in broad participation patient groups.


General anaesthesia; Intraocular pressure; Oleuropein; Rabbit; Rocuronium

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center