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Indian J Nucl Med. 2016 Jul-Sep;31(3):185-90. doi: 10.4103/0972-3919.183605.

Metastatic mimics on bone scan: "All that glitters is not metastatic".

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Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Mumbai, Maharashtra, India.


In this pictorial review, cases where benign diseases caused a diagnostic dilemma on bone scan are illustrated. This review highlights the value of correlative imaging- single-photon emission computed tomography/computed tomography (CT), CT, and magnetic resonance imaging in solving the diagnostic problem by exact localization and characterization of the lesions. All these eventually lead to increased diagnostic confidence, better and more accurate reporting and avoidance of delay in initiation of treatment due to equivocal results. The imaging features of these benign pathologies - which are "mimics of metastatic disease," are elaborated so that the reader can incorporate them while reporting so as to avoid mis-interpretations.


Benign; bone scan; computed tomography; metastasis; methylene diphosphonate; single-photon emission computed tomography

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