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Am J Clin Nutr. 2016 Aug;104(2):454-61. doi: 10.3945/ajcn.115.127985. Epub 2016 Jul 6.

The vitamin D status of the US population from 1988 to 2010 using standardized serum concentrations of 25-hydroxyvitamin D shows recent modest increases.

Author information

1
National Center for Environmental Health and the.
2
National Center for Health Statistics, CDC, Atlanta, GA; and the.
3
Office of Dietary Supplements, NIH, Bethesda, MD.
4
National Center for Environmental Health and the cfp8@cdc.gov.

Abstract

BACKGROUND:

Temporal trends in the US population's vitamin D status have been uncertain because of nonstandardized serum 25-hydroxyvitamin D [25(OH)D] measurements.

OBJECTIVE:

To accurately assess vitamin D status trends among those aged ≥12 y, we used data from the cross-sectional NHANESs.

DESIGN:

A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for measuring 25(OH)D (sum of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3), calibrated to standard reference materials, was used to predict LC-MS/MS-equivalent concentrations from radioimmunoassay data (1988-2006 surveys; n = 38,700) and to measure LC-MS/MS concentrations (2007-2010 surveys; n = 12,446). Weighted arithmetic means and the prevalence of 25(OH)D above or below cutoff concentrations were calculated to evaluate long-term trends.

RESULTS:

Overall, mean predicted 25(OH)D showed no time trend from 1988 to 2006, but during 2007-2010 the mean measured 25(OH)D was 5-6 nmol/L higher. Those groups who showed the largest 25(OH)D increases (7-11 nmol/L) were older, female, non-Hispanic white, and vitamin D supplement users. During 1988-2010, the proportions of persons with 25(OH)D <40 nmol/L were 14-18% (overall), 46-60% (non-Hispanic blacks), 21-28% (Mexican Americans), and 6-10% (non-Hispanic whites).

CONCLUSIONS:

An accurate method for measuring 25(OH)D showed stable mean concentrations in the US population (1988-2006) and recent modest increases (2007-2010). Although it is unclear to what extent supplement usage compared with different laboratory methods explain the increases in 25(OH)D, the use of higher vitamin D supplement dosages coincided with the increase. Marked race-ethnic differences in 25(OH)D concentrations were apparent. These data provide the first standardized information about temporal trends in the vitamin D status of the US population.

KEYWORDS:

NHANES; standardization; supplements; survey; trend; vitamin D

PMID:
27385610
PMCID:
PMC4962157
DOI:
10.3945/ajcn.115.127985
[Indexed for MEDLINE]
Free PMC Article

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