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Chem Asian J. 2016 Sep 20;11(18):2537-41. doi: 10.1002/asia.201600569. Epub 2016 Aug 5.

A Multifunctional Biomaterial with NIR Long Persistent Phosphorescence, Photothermal Response and Magnetism.

Wu Y1, Li Y2, Qin X1, Qiu J3,4.

Author information

1
State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Fiber Laser Materials and Applied Techniques, South China University of Technology, Guangzhou, 510640, P.R. China.
2
School of Physics & Optoelectronic Engineering, Guangdong University of Technology, Guangzhou, 510006, P.R. China. msliyang@scut.edu.cn.
3
State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Fiber Laser Materials and Applied Techniques, South China University of Technology, Guangzhou, 510640, P.R. China. qjr@scut.edu.cn.
4
College of Optical Science and Engineering, Zhejiang University, Hangzhou, 310007, P.R. China. qjr@scut.edu.cn.

Abstract

There are many reports on long persistent phosphors (LPPs) applied in bioimaging. However, there are few reports on LPPs applied in photothermal therapy (PTT), and an integrated system with multiple functions of diagnosis and therapy. In this work, we fabricate effective multifunctional phosphors Zn3 Ga2 SnO8 : Cr(3+) , Nd(3+) , Gd(3+) with NIR persistent phosphorescence, photothermal response and magnetism. Such featured materials can act as NIR optical biolabels and magnetic resonance imaging (MRI) contrast agents for tracking the early cancer cells, but also as photothermal therapeutic agent for killing the cancer cells. This new multifunctional biomaterial is expected to open a new possibility of setting up an advanced imaging-guided therapy system featuring a high resolution for bioimaging and low side effects for the photothermal ablation of tumors.

KEYWORDS:

long persistent phosphors; magnetism; multifunctional; photothermal response

PMID:
27385501
DOI:
10.1002/asia.201600569

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