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Pediatr Nephrol. 2016 Dec;31(12):2179-2189. Epub 2016 Jul 6.

Pathogenesis of proteinuria in idiopathic minimal change disease: molecular mechanisms.

Author information

1
Division of Pediatric Nephrology, Department of Pediatrics, University of Florida, 1600 SW Archer Road, HD214, Gainesville, FL, 32607, USA.
2
Department of Pathology, University of Florida, Gainesville, FL, USA.
3
Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado, Denver, CO, USA.
4
Division of Pediatric Nephrology, Department of Pediatrics, University of Florida, 1600 SW Archer Road, HD214, Gainesville, FL, 32607, USA. garineh@peds.ufl.edu.

Abstract

Minimal change disease (MCD) is the most common type of nephrotic syndrome in children and adolescents. The pathogenesis of proteinuria in this condition is currently being reassessed. Following the Shalhoub hypothesis, most efforts have been placed on identifying the putative circulating factor, but recent advancement in podocyte biology has focused attention on the molecular changes at the glomerular capillary wall, which could explain the mechanism of proteinuria in MCD. This report critically reviews current knowledge on the different postulated mechanisms at the glomerular capillary wall level for increased permeability to plasma proteins in MCD. The report helps describe the rationale behind novel therapies and suggests future targeted therapies for MCD.

KEYWORDS:

Angiopoietin-like 4; CD80; Minimal change disease; Nephrin phosphorylation; Podocytopathy

PMID:
27384691
DOI:
10.1007/s00467-016-3379-4
[Indexed for MEDLINE]

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