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Nature. 2016 Jul 7;535(7610):65-74. doi: 10.1038/nature18847.

The microbiome and innate immunity.

Author information

1
Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel.
2
Division of Internal Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel.
3
Research Center for Digestive Tract and Liver Diseases, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel.

Abstract

The intestinal microbiome is a signalling hub that integrates environmental inputs, such as diet, with genetic and immune signals to affect the host's metabolism, immunity and response to infection. The haematopoietic and non-haematopoietic cells of the innate immune system are located strategically at the host-microbiome interface. These cells have the ability to sense microorganisms or their metabolic products and to translate the signals into host physiological responses and the regulation of microbial ecology. Aberrations in the communication between the innate immune system and the gut microbiota might contribute to complex diseases.

PMID:
27383981
DOI:
10.1038/nature18847
[Indexed for MEDLINE]

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