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Bull Exp Biol Med. 2016 Jun;161(2):245-7. doi: 10.1007/s10517-016-3387-1. Epub 2016 Jul 7.

Neuroprotective Effectiveness of Intravenous Ubiquinone in Rat Model of Irreversible Cerebral Ischemia.

Author information

1
Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia. margarita.a.belousova@gmail.com.
2
Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia.

Abstract

The neuroprotective effect of ubiquinone (coenzyme Q10)was demonstrated on the rats model of ischemic stroke provoked by persistent 24-h occlusion of the middle cerebral artery. Coenzyme Q10 (30 mg/kg) was injected intravenously in 60 min after artery occlusion. Ubiquinone crossed the blood-brain barrier, accumulated in the brain, and produced a neuroprotective effect: it alleviated ischemia-induced neurological deficit and reduced the size of necrotic zone by 49% in comparison with rats receiving physiological saline.

KEYWORDS:

antioxidant; coenzyme Q 10 (ubiquinone); ischemic stroke; neuroprotection

PMID:
27383171
DOI:
10.1007/s10517-016-3387-1
[Indexed for MEDLINE]

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