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J Breast Cancer. 2016 Jun;19(2):206-9. doi: 10.4048/jbc.2016.19.2.206. Epub 2016 Jun 24.

Mu-Opioid Receptor Polymorphisms and Breast Cancer in a Korean Female Adult Population: A Retrospective Study.

Author information

1
Department of Anesthesiology and Pain Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.
2
Department of Microbiology, Konkuk University School of Medicine, Seoul, Korea.
3
Department of Surgery, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.
4
Department of Anesthesiology and Pain Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.; Institute of Biomedical Science and Technology, Konkuk University School of Medicine, Seoul, Korea.

Abstract

Distribution of A118G single nucleotide polymorphism (SNP) in the mu-opioid receptor 1 gene (OPRM1) differs with ethnicity. We assessed the distribution of this SNP in Korean women with breast cancer and compared it with that in women of other ethnicities with breast cancer. Distribution of SNP genotypes was as follows: 49.8% for AG genotype, 40.6% for AA genotype, and 9.6% for GG genotype. Logistic regression analysis showed a negative association between the presence of the G allele at position 118 of OPRM1 and breast cancer in the studied population (odds ratios [OR], 0.635; p=0.002). However, the AG and GG genotypes were not associated with breast cancer in the studied population (OR, 0.719; p=0.130). The proportions of the AG and GG genotypes of the OPRM1 SNP were higher in Korean women with breast cancer than in those of other ethnicities.

KEYWORDS:

Breast neoplasms; Genotype; Mu opioid receptors; Single nucleotide polymorphism

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