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J Investig Med. 2016 Aug;64(6):1075-7. doi: 10.1136/jim-2016-000210. Epub 2016 Jul 5.

Role of hepatic macrophages in alcoholic liver disease.

Author information

1
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Denver, Colorado, USA.
2
Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA Roudebush Veterans Administration Medical Center, Indianapolis, Indiana, USA.

Abstract

Alcohol consumption can lead to the increase in gut permeability and cause the translocation of bacteria-derived lipopolysaccharides from the gut to the liver, which subsequently activates immune responses. In this process, macrophages play a critical role and involve in the pathogenesis of alcoholic liver disease (ALD). To define the mechanism underpinning the function of macrophages, it is important to conduct extensive studies to further explicate the phenotypic diversity of macrophages in the context of ALD. In this review, the role of hepatic macrophages in the pathogenesis of ALD is discussed.

KEYWORDS:

Liver Diseases, Alcoholic; Macrophages

PMID:
27382116
PMCID:
PMC5495184
DOI:
10.1136/jim-2016-000210
[Indexed for MEDLINE]
Free PMC Article

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