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Stem Cells Transl Med. 2016 Sep;5(9):1162-70. doi: 10.5966/sctm.2015-0239. Epub 2016 Jul 5.

Adipose-Derived Mesenchymal Stem Cells Ameliorate Lipid Metabolic Disturbance in Mice.

Author information

1
Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.
2
Beijing Institute of Biotechnology, Beijing, People's Republic of China.
3
Department of Plastic Surgery, Chinese PLA General Hospital, Beijing, People's Republic of China.
4
Beijing Institute of Biotechnology, Beijing, People's Republic of China huxw1969@163.com duanhf0720@163.com.
5
Beijing Institute of Radiation Medicine, Beijing, People's Republic of China huxw1969@163.com duanhf0720@163.com.

Abstract

: Adipose-derived mesenchymal stem cells (AD-MSCs) have been shown to ameliorate hyperglycemia in diabetic animals and individuals. However, little is known about whether AD-MSCs affect lipid metabolism. Here we have demonstrated for the first time that AD-MSC infusion can significantly suppress the increase in body weight and remarkably improve dyslipidemia in db/db obese mice and diet-induced obesity mice. Induction of white fat tissue "browning" and activation of adenosine monophosphate-activated protein kinase and its downstream hormone-sensitive lipase in adipose tissue contribute to the antiobesity and lipid-lowering effects. Thus, AD-MSC infusion holds great therapeutic potential for dyslipidemia and associated cardiovascular diseases.

SIGNIFICANCE:

Mesenchymal stem cells (MSCs) are considered one of the most promising types of stem cells for translational application because of their rich tissue sources, multilineage differentiation capacity, and easy amplification in vitro and unique immunobiological properties. This study demonstrated that adipose-derived MSCs (AD-MSCs) infusion can significantly suppress the increase in body weight and remarkably improve dyslipidemia in obese mice. Induction of white fat tissue "browning" and activation of adenosine monophosphate-activated protein kinase and its downstream hormone-sensitive lipase in adipose tissue were demonstrated to contribute to the antiobesity and lipid-lowering effects. Thus, AD-MSC infusion holds great therapeutic potential for dyslipidemia.

KEYWORDS:

Adenosine monophosphate-activated protein kinase; Adipose-derived mesenchymal stem cell; Anti-obesity; Lipid metabolism

PMID:
27381991
PMCID:
PMC4996437
DOI:
10.5966/sctm.2015-0239
[Indexed for MEDLINE]
Free PMC Article

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