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Int J Biol Macromol. 2016 Nov;92:278-281. doi: 10.1016/j.ijbiomac.2016.07.005. Epub 2016 Jul 2.

Protective roles of polysaccharides from Ganoderma lucidum on bleomycin-induced pulmonary fibrosis in rats.

Author information

1
Department of Respiratory Medicine, Xiangya Hospital of Central South University, Key Site of National Clinical Research Center for Respiratory Disease, Changsha 410008, PR China; Department of Respiratory Medicine, Huai'an Second People's Hospital, Huai'an 223002, Jiangsu, PR China.
2
School of Chemical Engineering, Huaiyin Institute of Technology, Huai'an 223003, Jiangsu, PR China.
3
Xinhua College, Sun Yat-sen University, Guangzhou 510520, Guangdong, PR China.
4
Department of Respiratory Medicine, Huai'an Second People's Hospital, Huai'an 223002, Jiangsu, PR China.
5
Department of Respiratory Medicine, Huai'an First People's Hospital, Nanjing Medical University, Huai'an 223300, Jiangsu, PR China.
6
Department of Respiratory Medicine, Xiangya Hospital of Central South University, Key Site of National Clinical Research Center for Respiratory Disease, Changsha 410008, PR China. Electronic address: cjh0517@sohu.com.

Abstract

The purpose of this paper was to investigate the protective effects of polysaccharides from (PGL) Ganoderma lucidum on bleomycin-induced pulmonary fibrosis in rats. Our study demonstrated that treatment with PGL of 100-300mg/kg for 28 days led to significant reduction in the pulmonary index, inflammatory cell infiltration and collagen deposition in rats with bleomycin-induced pulmonary fibrosis, which was associated with increased levels of glutathione, glutathione peroxidase, catalase and superoxide dismutase and decreased contents of malondialdehyde and hydroxyproline in the lung. These results indicated that PGL played a positive protective role in the pulmonary fibrosis and its possible mechanism was to improve lung antioxidant ability.

KEYWORDS:

Polysaccharides from Ganoderma lucidum; Protective role; Pulmonary fibrosis

PMID:
27381587
DOI:
10.1016/j.ijbiomac.2016.07.005
[Indexed for MEDLINE]

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