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Biosci Biotechnol Biochem. 2016 Oct;80(10):2014-7. doi: 10.1080/09168451.2016.1184558. Epub 2016 Jul 4.

Activation of human bitter taste receptors by polymethoxylated flavonoids.

Author information

1
a Graduate School of Integrated Pharmaceutical and Nutritional Sciences , University of Shizuoka , Shizuoka , Japan.

Abstract

Tangeretin and nobiletin are polymethoxylated flavonoids in citrus peel. Both tangeretin and nobiletin are bitter; however, their bitterness has not been evaluated using human bitter taste receptors (hTAS2Rs). We screened 25 kinds of hTAS2Rs and found that hTAS2R14 and hTAS2R46 received both compounds.

KEYWORDS:

hTAS2R14; hTAS2R46; nobiletin; polymethoxylated flavonoids; tangeretin

PMID:
27379685
DOI:
10.1080/09168451.2016.1184558
[Indexed for MEDLINE]

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