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J Egypt Natl Canc Inst. 2016 Dec;28(4):257-262. doi: 10.1016/j.jnci.2016.06.001. Epub 2016 Jul 1.

Prevalence of hepatocellular carcinoma in chronic hepatitis C patients in Mid Delta, Egypt: A single center study.

Author information

1
Tropical Medicine, Faculty of Medicine, Tanta University, Egypt.
2
Tropical Medicine, Faculty of Medicine, Tanta University, Egypt; Faculty of Medicine, King Abdulaziz University KSA, Egypt.
3
Tropical Medicine, Faculty of Medicine, Tanta University, Egypt. Electronic address: Sherif_tropical@yahoo.com.
4
Internal Medicine, Faculty of Medicine, Tanta University, Egypt.
5
Radiology, Faculty of Medicine, Tanta University, Egypt.
6
Public Health and Community Medicine Departments, Faculty of Medicine, Tanta University, Egypt.

Abstract

BACKGROUND AND AIM:

Hepatocellular carcinoma (HCC) has an increasing incidence worldwide. In this study we aimed to assess the prevalence of HCC among HCV patients in our center in Mid Delta, Egypt.

PATIENTS AND METHODS:

During the period between April 2013 and January 2015, we screened sequentially chronic HCV patients attending inpatient wards or outpatient Clinic of Tropical Medicine Department in Tanta University Hospital for HCC. Individuals with focal lesion in Ultrasound (US) and/or serum α-fetoprotein (AFP) level >200ng/ml were examined by triphasic computed tomography scanning (CT), and/or magnetic resonance imaging (MRI).

RESULTS:

Among 514 HCV patients interviewed and accepted sharing in this study, 90 (17.5%), 144 (28%), and 280 (54.5%) were Child A, B, and C, respectively. We found that 108/514 patients (21%) had focal lesion detected by US. Also, 89/514 (17.3%) had elevated AFP >200, 13 of them (14.6%) had no focal lesion on US, but further work up showed HCC in 2 of them. Overall HCC diagnosis was confirmed in 103 cases, 94 of them (91.3%) were Child B or C. Occurrence of HCC was significantly higher in smokers, diabetics, patients with decompensated liver and those with positive family history of HCC. Only 20/103 (19.4%) were candidates to curative treatments, 8 of them were Child A asymptomatic and discovered accidentally during screening.

CONCLUSION:

The high prevalence of HCC in our HCV patients (22%) was mainly associated with decompensated cirrhosis. A national surveillance program for the detection of HCC in cirrhotic HCV Egyptian patients by combining ultrasound examination and AFP is highly recommended.

KEYWORDS:

Chronic hepatitis C; Egypt; Epidemiology; Hepatocellular carcinoma; Prevalence; Screening

PMID:
27378258
DOI:
10.1016/j.jnci.2016.06.001
[Indexed for MEDLINE]
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