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Mol Nutr Food Res. 2017 Jan;61(1). doi: 10.1002/mnfr.201500906. Epub 2016 Aug 3.

Pterostilbene-induced changes in gut microbiota composition in relation to obesity.

Author information

1
Department of Nutrition, Food Science and Physiology, and Centre for Nutrition Research University of Navarra, Pamplona, Spain.
2
Department of Gastroenterology, Donostia Hospital and Biodonostia Institute, University of the Basque Country (UPV/EHU), San Sebastián, Spain.
3
CIBER Hepatic and Digestive Pathologies (CIBERehd), Institute of Health Carlos III, Madrid, Spain.
4
CIBER Obesity and Physiopathology of Nutrition (CIBERobn), Institute of Health Carlos III, Madrid, Spain.
5
Nutrition and Obesity Group, Department of Nutrition and Food Sciences, Faculty of Pharmacy, University of the Basque Country (UPV/EHU) and Lucio Lascaray Research Centre, Vitoria, Spain.
6
United States Department of Agriculture, Agricultural Research Service Natural Products Utilization Research Unit, University, MS, USA.

Abstract

SCOPE:

Nutritional interventions based on the use of natural bioactive compounds might offer new possibilities for reshaping obesity-associated bacterial dysregulation or dysbiosis and improving health. We evaluated whether pterostilbene supplementation could induce changes in gut microbiota composition and whether these modifications were associated with improvements in metabolic variables.

METHODS AND RESULTS:

Zucker (fa/fa) rats were given a standard diet supplemented (n = 10) or not (n = 9) with pterostilbene (15 mg/kg body weight/day) by oral gavage for 6 weeks. Faucal samples at the beginning and at the end of the intervention period were analyzed by Illumina Mi-Seq sequencing approach. Pterostilbene exerted protective antiobesity effects, improved metabolic function (insulin sensitivity), and induced structural changes in gut microbiota composition. A decrease in the levels of Firmicutes and an increase in Verrucomicrobia phyla were detected in the pterostilbene-treated group. Bacterial species belonging to genera Akkermansia and Odoribacter were also increased. A strong inverse correlation between Akkermansia muciniphila and body weight was evidenced. Odoribacter splanchnicus showed a negative correlation with adiposity.

CONCLUSION:

Pterostilbene modifies intestinal bacteria composition toward a healthier microbial profile and suggests that the antiobesity effects induced in Zucker rats could be associated with an enrichment of the mucin-degrading bacterial members, namely Akkermansia and Odoribacter genus.

KEYWORDS:

Akkermansia; Insulin sensitivity; Odoribacter; Polyphenols; Verrucomicrobia

PMID:
27377854
DOI:
10.1002/mnfr.201500906
[Indexed for MEDLINE]

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