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Semin Cell Dev Biol. 2017 Jan;61:150-155. doi: 10.1016/j.semcdb.2016.06.020. Epub 2016 Jun 29.

Peromyscus as a model of human disease.

Author information

1
Department of Drug Discovery and Biomedical Sciences, University of South Carolina, SC, USA; Peromyscus Genetic Stock Center, Office of Research, University of South Carolina, SC, USA.
2
Peromyscus Genetic Stock Center, Office of Research, University of South Carolina, SC, USA.
3
Department of Drug Discovery and Biomedical Sciences, University of South Carolina, SC, USA; Peromyscus Genetic Stock Center, Office of Research, University of South Carolina, SC, USA; Department of Biochemistry, University of Athens Medical School, Athens, Greece. Electronic address: kiarish@sccp.sc.edu.

Abstract

Animals of the genus Peromyscus have been a particularly informative model for many areas of study, including behavior, evolution, anatomy, physiology and genetics. While their use in modeling human disease and pathology has been relatively restricted, certain qualities of Peromyscine mice may make them a good candidate for such studies. Pathophysiological conditions where Peromyscus may be of particular value involve aging, reactive oxygen species-associated pathologies, metabolism and detoxification, diabetes, and certain cancers. In this review article we will summarize pathological conditions where Peromyscus have been used effectively, we will discuss factors limiting the use of Peromyscus in studying pathology and we will indicate areas at which the use of this model may be of special value.

KEYWORDS:

Alcohol metabolism; Cancer; Diabetes; Hypoxia; Model organism; Oxidative stress; Pathology; Peromyscus

PMID:
27375227
DOI:
10.1016/j.semcdb.2016.06.020
[Indexed for MEDLINE]

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