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Mitochondrion. 2016 Sep;30:35-41. doi: 10.1016/j.mito.2016.06.005. Epub 2016 Jun 29.

Mitochondrial function is altered in horse atypical myopathy.

Author information

1
Faculty Saint-Jean, University of Alberta, Edmonton, Alberta, Canada.
2
Biochemical Genetics Laboratory, Human Genetics, CHU Liege, University of Liege, Belgium.
3
(c)Equine Clinic, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liege, Belgium.
4
(c)Equine Clinic, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liege, Belgium; Centre of Oxygen, Research and Development, University of Liege, Liege, Belgium.
5
(e)Department of Animal Productions: Biostatistics, Economy and Animal Selection, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liege, Belgium.
6
Department of Pathology, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liege, Belgium.
7
(g)Large Animal Internal Medicine, Ghent University, Belgium.
8
(h)Réseau d'EpidémioSurveillance en Pathologie Equine (RESPE), Caen, France.
9
(i)Equine Pole, Fundamental and Applied Research for Animals and Health (FARAH), Faculty of Veterinary Medicine, University of Liege, Belgium. Electronic address: dominique.votion@ulg.ac.be.

Abstract

Equine atypical myopathy in Europe is a fatal rhabdomyolysis syndrome that results from the ingestion of hypoglycin A contained in seeds and seedlings of Acer pseudoplatanus (sycamore maple). Acylcarnitine concentrations in serum and muscle OXPHOS capacity were determined in 15 atypical myopathy cases. All but one acylcarnitine were out of reference range and mitochondrial respiratory capacity was severely decreased up to 49% as compared to 10 healthy controls. The hallmark of atypical myopathy thus consists of a severe alteration in the energy metabolism including a severe impairment in muscle mitochondrial respiration that could contribute to its high death rate.

KEYWORDS:

Acer; Acylcarnitines; High-resolution respirometry; Horse; Methylenecyclopropyl acetic acid-CoA; Rhabdomyolysis; Skeletal muscle

PMID:
27374763
DOI:
10.1016/j.mito.2016.06.005
[Indexed for MEDLINE]

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