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Biol Pharm Bull. 2016;39(7):1159-66. doi: 10.1248/bpb.b16-00124.

Is Coenzyme Q10 Effective in Protection against Ulcerative Colitis? An Experimental Study in Rats.

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1
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Nahda University.

Abstract

Coenzyme Q10 (Co-Q10) is a vitamin-like supplement which appears to be safe, with minimal side effects and low drug interaction potential. Co-Q10 is used in the treatment of a variety of disorders related primarily to suboptimal cellular energy metabolism and oxidative injury. Studies supporting the efficacy of Co-Q10 appear most promising for a variety of diseases, including ulcerative colitis (UC). The present investigation aims to elucidate the possible protective effects of Co-Q10 against UC, as induced by the administration of iodoacetamide to adult male albino rats. In our study, Co-Q10 showed potent anti-oxidant and anti-inflammatory activities through a significant increase in catalase activity and glutathione content. In addition, it significantly decreased myeloperoxidase activity, malondialdehyde content and nitrate/nitrite production. These results suggest that Co-Q10 protects against UC in rats via anti-oxidant and anti-inflammatory potentials, and therefore seems promising for use in further clinical trials.

PMID:
27374290
DOI:
10.1248/bpb.b16-00124
[Indexed for MEDLINE]
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