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Neuron. 2016 Jul 20;91(2):384-96. doi: 10.1016/j.neuron.2016.06.004. Epub 2016 Jun 30.

Persistent Structural Plasticity Optimizes Sensory Information Processing in the Olfactory Bulb.

Author information

1
Laboratory for Perception and Memory, Pasteur Institute, 75015 Paris, France; Centre National de la Recherche Scientifique (CNRS), Unité de Recherche Associée (UMR3571), 75015 Paris, France; Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA; The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N. Wolf Street, Baltimore, MD 21205, USA; Diana Helis Henry Medical Research Foundation, New Orleans, LA 70130-2685, USA.
2
Laboratory for Perception and Memory, Pasteur Institute, 75015 Paris, France; Centre National de la Recherche Scientifique (CNRS), Unité de Recherche Associée (UMR3571), 75015 Paris, France.
3
Engineering Science and Applied Mathematics, Northwestern University, Evanston, IL 60208, USA.
4
Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA; The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N. Wolf Street, Baltimore, MD 21205, USA.
5
Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA; The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N. Wolf Street, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, 600 N. Wolf Street, Baltimore, MD 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Diana Helis Henry Medical Research Foundation, New Orleans, LA 70130-2685, USA.
6
Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA; The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N. Wolf Street, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, 600 N. Wolf Street, Baltimore, MD 21205, USA; Diana Helis Henry Medical Research Foundation, New Orleans, LA 70130-2685, USA. Electronic address: shongju1@jhmi.edu.
7
Laboratory for Perception and Memory, Pasteur Institute, 75015 Paris, France; Centre National de la Recherche Scientifique (CNRS), Unité de Recherche Associée (UMR3571), 75015 Paris, France. Electronic address: pierre-marie.lledo@pasteur.fr.

Abstract

In the mammalian brain, the anatomical structure of neural circuits changes little during adulthood. As a result, adult learning and memory are thought to result from specific changes in synaptic strength. A possible exception is the olfactory bulb (OB), where activity guides interneuron turnover throughout adulthood. These adult-born granule cell (GC) interneurons form new GABAergic synapses that have little synaptic strength plasticity. In the face of persistent neuronal and synaptic turnover, how does the OB balance flexibility, as is required for adapting to changing sensory environments, with perceptual stability? Here we show that high dendritic spine turnover is a universal feature of GCs, regardless of their developmental origin and age. We find matching dynamics among postsynaptic sites on the principal neurons receiving the new synaptic inputs. We further demonstrate in silico that this coordinated structural plasticity is consistent with stable, yet flexible, decorrelated sensory representations. Together, our study reveals that persistent, coordinated synaptic structural plasticity between interneurons and principal neurons is a major mode of functional plasticity in the OB.

PMID:
27373833
PMCID:
PMC5476833
DOI:
10.1016/j.neuron.2016.06.004
[Indexed for MEDLINE]
Free PMC Article

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