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Med Hypotheses. 2016 Aug;93:5-7. doi: 10.1016/j.mehy.2016.04.045. Epub 2016 Apr 30.

Hydroxychloroquine, a promising choice for coronary artery disease?

Author information

1
Department of Cardiovascular Medicine, First Affiliated Hospital of Medical School, Xi'an Jiaotong University. Xi'an 710061, PR China.
2
Department of Cardiovascular Medicine, First Affiliated Hospital of Medical School, Xi'an Jiaotong University. Xi'an 710061, PR China; Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Ministry of Education, Xi'an 710061, PR China. Electronic address: zuyiyuan@mail.xjtu.edu.cn.
3
Department of Cardiovascular Medicine, First Affiliated Hospital of Medical School, Xi'an Jiaotong University. Xi'an 710061, PR China; Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Ministry of Education, Xi'an 710061, PR China. Electronic address: imyuewu@gmail.com.

Abstract

Coronary artery disease is a common disease that seriously threaten the health of more than 150 million people per year. Atherosclerosis is considered to be the main cause of coronary artery disease which begins with damage or injury to the inner layer of a coronary artery, sometimes as early as childhood. The damage may be caused by various factors, including: smoking, high blood pressure, hypercholesterolemia, sedentary lifestyle, diabetes and insulin resistance. Once a coronary artery disease has developed, all patients need to be treated with long term standard treatment, including heart-healthy lifestyle changes, medicines, and medical procedures or surgery. Hydroxychloroquine, an original antimalarial drug, prevents inflammation caused by lupus erythematosus and rheumatoid arthritis. It is relatively safe and well-tolerated during the treatment. Since atherosclerosis and rheumatoid arthritis have resemble mechanism and increasing clinical researches confirm that hydroxychloroquine has an important role in both anti-rheumatoid arthritis and cardiovascular protection (such as anti-platelet, anti-thrombotic, lipid-regulating, anti-hypertension, hypoglycemia, and so on), we hypothesize that hydroxychloroquine might be a promising choice to coronary artery disease patients for its multiple benefits.

KEYWORDS:

Atherosclerosis; Coronary artery disease; Hydroxychloroquine

PMID:
27372847
DOI:
10.1016/j.mehy.2016.04.045
[Indexed for MEDLINE]

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