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Allergol Int. 2016 Sep;65 Suppl:S2-5. doi: 10.1016/j.alit.2016.05.010. Epub 2016 Jun 29.

Eosinophil polyunsaturated fatty acid metabolism and its potential control of inflammation and allergy.

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Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan; Graduate School of Medical Life Science, Yokohama City University, Kanagawa, Japan; Division of Physiological Chemistry and Metabolism, Graduate School of Pharmaceutical Sciences, Keio University, Tokyo, Japan. Electronic address:


Polyunsaturated fatty acids (PUFAs) exhibit a range of biological effects, many of which are mediated through the formation and actions of their bioactive metabolites. It is well appreciated that dietary PUFA balance affects inflammation and/or allergic diseases, and recent advances in liquid chromatography tandem mass spectrometry (LC-MS/MS)-based mediator lipidomics have revealed a potential link between PUFA metabolism and biological phenotypes. This review presents insights into the emerging roles of eosinophil PUFA metabolism in controlling inflammatory responses and its potential involvement in allergy control.


Eosinophil; Lipid mediator; Lipidomics; Lipoxygenase; n-3 fatty acid

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