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Int J Dermatol. 2016 Oct;55(10):1157-63. doi: 10.1111/ijd.13258. Epub 2016 Jul 1.

Effects of repetitive photodynamic therapy using indocyanine green for acne vulgaris.

Author information

1
Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
2
CleanUp Dermatologic Clinic, Seoul, Korea.
3
Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. susini@naver.com.

Abstract

BACKGROUND:

Indocyanine green (ICG) is a photosensitizer recently introduced for the treatment of acne.

OBJECTIVE:

To evaluate the efficacy and safety of photodynamic therapy (PDT) using ICG in subjects with acne vulgaris and to evaluate whether there was a difference in the efficacy of ICG-PDT between different numbers of treatment.

MATERIALS AND METHODS:

Subjects with acne on the face were included. ICG lotion (0.1%) was applied for 30 minutes, and a long pulse diode laser was used. Three or five treatments per subject were performed over 2 weeks. Acne lesion counts and Leeds revised acne grades were evaluated at baseline and 2 weeks after the last treatment.

RESULTS:

In total, 47 subjects completed the study. After both three and five ICG-PDT sessions, a significant reduction in acne lesions and significant improvement in Leeds revised acne grades were found in all treated subjects compared to baseline. In the subjects receiving five ICG-PDT sessions, the reduction of papules/pustules was greater than in the subjects receiving three ICG-PDT sessions (P < 0.01, respectively). However, there was no significant change in the count of nodules/cysts, although it is a negative trend (P = 0.066). Adverse effects were minimal.

CONCLUSION:

ICG-PDT using long-pulsed diode laser can be a safe and effective tool for acne vulgaris. Moreover, repetitive treatments of five can cause further improvement of inflammatory acne lesions.

KEYWORDS:

Acne vulgaris; Photodynamic therapy

PMID:
27371428
DOI:
10.1111/ijd.13258
[Indexed for MEDLINE]

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