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Med Phys. 2016 Jul;43(7):4383. doi: 10.1118/1.4953830.

Heterodyne frequency-domain multispectral diffuse optical tomography of breast cancer in the parallel-plane transmission geometry.

Author information

1
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
2
Department of Computer Science, University College London, London WC1E 7JE, United Kingdom.
3
Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
4
Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104.
5
Faculty of Electrical Engineering, University of Ljubljana, Ljubljana 1000, Slovenia.
6
Daegu Gyeongbuk Institute of Science and Technology, Daegu 711-813, South Korea.
7
Department of Biomedical Engineering, University of Rochester, Rochester, New York 14642.
8
Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104.

Abstract

PURPOSE:

The authors introduce a state-of-the-art all-optical clinical diffuse optical tomography (DOT) imaging instrument which collects spatially dense, multispectral, frequency-domain breast data in the parallel-plate geometry.

METHODS:

The instrument utilizes a CCD-based heterodyne detection scheme that permits massively parallel detection of diffuse photon density wave amplitude and phase for a large number of source-detector pairs (10(6)). The stand-alone clinical DOT instrument thus offers high spatial resolution with reduced crosstalk between absorption and scattering. Other novel features include a fringe profilometry system for breast boundary segmentation, real-time data normalization, and a patient bed design which permits both axial and sagittal breast measurements.

RESULTS:

The authors validated the instrument using tissue simulating phantoms with two different chromophore-containing targets and one scattering target. The authors also demonstrated the instrument in a case study breast cancer patient; the reconstructed 3D image of endogenous chromophores and scattering gave tumor localization in agreement with MRI.

CONCLUSIONS:

Imaging with a novel parallel-plate DOT breast imager that employs highly parallel, high-resolution CCD detection in the frequency-domain was demonstrated.

PMID:
27370153
PMCID:
PMC4920810
DOI:
10.1118/1.4953830
[Indexed for MEDLINE]
Free PMC Article

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