Format

Send to

Choose Destination
Jpn J Clin Oncol. 2016 Jun;46(6):580-95. doi: 10.1093/jjco/hyw027. Epub 2016 Apr 24.

Cigarette smoking and the risk of head and neck cancer in the Japanese population: a systematic review and meta-analysis.

Author information

1
Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya.
2
Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya kmatsuo@aichi-cc.jp.
3
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya.
4
Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya.
5
Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Gifu.
6
Center for Cancer Control and Statistics, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka.
7
Department of Epidemiology, Radiation Effects Research Foundation, Hiroshima.
8
Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga.
9
Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo.
10
Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, Sendai.
11
Department of Epidemiology and International Health, International Clinical Research Center, National Center for Global Health and Medicine, Tokyo.
12
Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo.
13
Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo AXA Department of Health and Human Security, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.

Abstract

OBJECTIVE:

Although cigarette smoking is a well-established risk factor for head and neck cancer, the impact of smoking on head and neck cancer might vary among geographic areas. To date, however, no systematic review of cigarette smoking and head and neck cancer in the Japanese population has yet appeared.

METHODS:

We conducted a systematic review of previous epidemiological studies for cigarette smoking and head and neck cancer among Japanese. Evaluation of associations was based on the strength of evidence ('convincing', 'probable', 'possible' or 'insufficient') and the magnitude of association ('strong', 'moderate', 'weak' or 'no association'), together with biological plausibility as previously evaluated by the International Agency for Research on Cancer. A meta-analysis was conducted to obtain summary estimates for the overall magnitude of association.

RESULTS:

We identified five cohort studies and 12 case-control studies. Four of five cohort studies and 11 of 12 case-control studies showed a strong positive association between cigarette smoking and head and neck cancer. Nine of 12 studies indicated a dose-response relationship between cigarette smoking and the risk of head and neck cancer. Meta-analysis of 12 studies indicated that the summary relative risk for ever smokers relative to never smokers was 2.43 (95% confidence interval: 2.09-2.83). Summary relative risks for current and former smokers relative to never smokers were 2.68 (2.08-3.44) and 1.49 (1.05-2.11), respectively.

CONCLUSIONS:

Cigarette smoking is a convincing risk factor for head and neck cancer in the Japanese population.

KEYWORDS:

Japanese; cigarette smoking; epidemiology; head and neck cancer; systematic review

PMID:
27369767
DOI:
10.1093/jjco/hyw027
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center