Format

Send to

Choose Destination
Neuropsychiatr Dis Treat. 2016 Jun 15;12:1397-410. doi: 10.2147/NDT.S107545. eCollection 2016.

Anterior cingulate hyperactivations during negative emotion processing among men with schizophrenia and a history of violent behavior.

Author information

1
Centre de recherche de l'Institut Universitaire en Santé Mentale de Montréal, Trois-Rivières, QC, Canada; Department of Psychiatry, University of Montreal, Trois-Rivières, QC, Canada.
2
Department of Psychiatry, University of Montreal, Trois-Rivières, QC, Canada; Centre de recherche de l'Institut Universitaire de Gériatrie de Montréal, Trois-Rivières, QC, Canada; Centre for Research in Aging, Donald Berman Maimonides Geriatric Centre, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada.
3
Institut Philippe-Pinel de Montréal, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada; Department of Psychology, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada.
4
Department of Psychiatry, University of Montreal, Trois-Rivières, QC, Canada; Institut Philippe-Pinel de Montréal, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada.
5
Centre de recherche de l'Institut Universitaire en Santé Mentale de Montréal, Trois-Rivières, QC, Canada; Department of Psychology, Bishop's University, Sherbrooke, QC, Canada.
6
Centre de recherche de l'Institut Universitaire en Santé Mentale de Montréal, Trois-Rivières, QC, Canada; Department of Psychiatry, University of Montreal, Trois-Rivières, QC, Canada; Institut Philippe-Pinel de Montréal, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada.

Abstract

BACKGROUND:

Evidence suggests a 2.1-4.6 times increase in the risk of violent behavior in schizophrenia compared to the general population. Current theories propose that the processing of negative emotions is defective in violent individuals and that dysfunctions within the neural circuits involved in emotion processing are implicated in violence. Although schizophrenia patients show enhanced sensitivity to negative stimuli, there are only few functional neuroimaging studies that have examined emotion processing among men with schizophrenia and a history of violence.

OBJECTIVE:

The present study aimed to identify the brain regions with greater neurofunctional alterations, as detected by functional magnetic resonance imaging during an emotion processing task, of men with schizophrenia who had engaged in violent behavior compared with those who had not.

METHODS:

Sixty men were studied; 20 with schizophrenia and a history of violence, 19 with schizophrenia and no violence, and 21 healthy men were scanned while viewing positive, negative, and neutral images.

RESULTS:

Negative images elicited hyperactivations in the anterior cingulate cortex (ACC), left and right lingual gyrus, and the left precentral gyrus in violent men with schizophrenia, compared to nonviolent men with schizophrenia and healthy men. Neutral images elicited hyperactivations in the right and left middle occipital gyrus, left lingual gyrus, and the left fusiform gyrus in violent men with schizophrenia, compared to the other two groups.

DISCUSSION:

Violent men with schizophrenia displayed specific increases in ACC in response to negative images. Given the role of the ACC in information integration, these results indicate a specific dysfunction in the processing of negative emotions that may trigger violent behavior in men with schizophrenia.

KEYWORDS:

anterior cingulate cortex; fMRI; negative emotions; salience; schizophrenia; violence

Supplemental Content

Full text links

Icon for Dove Medical Press Icon for PubMed Central
Loading ...
Support Center