Format

Send to

Choose Destination
J Korean Med Sci. 2016 Jul;31(7):1082-8. doi: 10.3346/jkms.2016.31.7.1082. Epub 2016 Apr 27.

Early Changes in the Serotype Distribution of Invasive Pneumococcal Isolates from Children after the Introduction of Extended-valent Pneumococcal Conjugate Vaccines in Korea, 2011-2013.

Author information

1
Seoul National University College of Medicine, Seoul, Korea.; Chungnam National University Hospital, Daejeon, Korea.
2
Seoul National University College of Medicine, Seoul, Korea .
3
College of Medicine, the Catholic University of Korea, Seoul, Korea .
4
School of Medicine, Ewha Womans University, Seoul, Korea .
5
Yonsei University College of Medicine, Seoul, Korea .
6
Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea .
7
Eulji University School of Medicine, Daejeon, Korea .
8
Hanyang University, College of Medicine, Seoul, Korea .
9
Kyung Hee University School of Medicine, Seoul, Korea .
10
Graduate School of Medicine, Gachon University, Incheon, Korea .
11
Inha University School of Medicine, Incheon, Korea .
12
Hallym University College of Medicine, Chuncheon, Korea .
13
Inje University College of Medicine, Seoul, Korea .
14
Korea University College of Medicine, Seoul, Korea .
15
Seoul National University Bundang Hospital, Seoul, Korea .
16
CHA Bundang Medical Center, CHA University, Seoul, Korea .
17
Yonsei University Wonju College of Medicine, Wonju, Korea .
18
College of Medicine, Dankook University, Cheonan, Korea .
19
Keimyung University School of Medicine, Daegu, Korea .
20
Pusan National University School of Medicine, Busan, Korea .
21
Kosin University College of Medicine, Busan, Korea .
22
Changwon Fatima Hospital, Changwon, Korea .
23
Chonbuk National University Medical School, Jeonju, Korea .
24
Chonnam National University Medical School, Gwangju, Korea .
25
University of Ulsan College of Medicine, Seoul, Korea .
26
Korea Centers for Disease Control and Prevention, Cheongju, Korea .

Abstract

This study was performed to measure early changes in the serotype distribution of pneumococci isolated from children with invasive disease during the 3-year period following the introduction of 10- and 13-valent pneumococcal conjugate vaccines (PCVs) in Korea. From January 2011 to December 2013 at 25 hospitals located throughout Korea, pneumococci were isolated among children who had invasive pneumococcal disease (IPD). Serotypes were determined using the Quellung reaction, and the change in serotype distribution was analyzed. Seventy-five cases of IPD were included. Eighty percent of patients were aged 3-59 months, and 32% had a comorbidity that increased the risk of pneumococcal infection. The most common serotypes were 19A (32.0%), 10A (8.0%), and 15C (6.7%). The PCV7 serotypes (4, 6B, 9V, 14, 18C, 19F, 23F, and 6A) accounted for 14.7% of the total isolates and the PCV13 minus PCV7 types (1, 3, 5, 7F and 19A) accounted for 32.0% of the total isolates. Serotype 19A was the only serotype in the PCV13 minus PCV7 group. The proportion of serotype 19A showed decreasing tendency from 37.5% in 2011 to 22.2% in 2013 (P = 0.309), while the proportion of non-PCV13 types showed increasing tendency from 45.8% in 2011 to 72.2% in 2013 (P = 0.108). Shortly after the introduction of extended-valent PCVs in Korea, serotype 19A continued to be the most common serotype causing IPD in children. Subsequently, the proportion of 19A decreased, and non-vaccine serotypes emerged as an important cause of IPD. The impact of extended-valent vaccines must be continuously monitored.

KEYWORDS:

Pneumococcal Vaccines; Serotype; Streptococcus pneumoniae

PMID:
27366006
PMCID:
PMC4901000
DOI:
10.3346/jkms.2016.31.7.1082
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Korean Academy of Medical Sciences Icon for PubMed Central
Loading ...
Support Center