Granuloma faciale successfully treated with ingenol mebutate

Dermatol Ther. 2016 Sep;29(5):325-329. doi: 10.1111/dth.12368. Epub 2016 Jun 30.

Abstract

Granuloma faciale (GF) is a rare chronic inflammatory dermatosis of unknown etiology, characterized by leukocitoclastic vasculitis usually occurring on the face. We report a case of 60-years-old man with 3 year history of multiple actinic keratoses (AK) and persistent asymptomatic erythematous papules and plaques located over his left temporal region and the cheek: histopathology was consistent with GF. Herein we describe the successful treatment of the lesion with ingenol mebutate 0.015% gel focusing on the clinical, dermoscopic and histopathological findings of GF both before and after treatment.

Keywords: granuloma faciale; ingenol mebutate; off label treatment.

Publication types

  • Case Reports

MeSH terms

  • Administration, Cutaneous
  • Biopsy
  • Dermatologic Agents / administration & dosage
  • Dermatologic Agents / therapeutic use*
  • Dermoscopy
  • Diterpenes / administration & dosage
  • Diterpenes / therapeutic use*
  • Facial Dermatoses / diagnosis
  • Facial Dermatoses / drug therapy*
  • Gels
  • Granuloma / diagnosis
  • Granuloma / drug therapy*
  • Humans
  • Keratosis, Actinic / diagnosis
  • Keratosis, Actinic / drug therapy*
  • Male
  • Middle Aged
  • Remission Induction
  • Skin / drug effects*
  • Skin / pathology
  • Treatment Outcome

Substances

  • 3-ingenyl angelate
  • Dermatologic Agents
  • Diterpenes
  • Gels