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J Clin Endocrinol Metab. 2016 Sep;101(9):3361-9. doi: 10.1210/jc.2016-2081. Epub 2016 Jun 30.

Circulating Cytokines Predict the Development of Insulin Resistance in a Prospective Finnish Population Cohort.

Author information

1
MediCity Research Laboratory and Department of Medical Microbiology and Immunology (K.S., M.M., S.J., M.S.), University of Turku, Turku, Finland; Department of Information Technology (A.A., T.P.), University of Turku, Turku, Finland; Department of Pediatrics (N.H.-K.), University of Tampere and Tampere University Hospital, Tampere, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine (O.T.R.), University of Turku and Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.

Abstract

CONTEXT:

Metabolic inflammation contributes to the development of insulin resistance (IR), but the roles of different inflammatory and other cytokines in this process remain unclear.

OBJECTIVE:

We aimed at analyzing the value of different cytokines in predicting future IR.

DESIGN, SETTING, AND PARTICIPANTS:

We measured the serum concentrations of 48 cytokines from a nationwide cohort of 2200 Finns (the Cardiovascular Risk in Young Finns Study), and analyzed their role as independent risk factors for predicting the development of IR 4 years later.

MAIN OUTCOME MEASURES:

We used cross-sectional regression analysis adjusted for known IR risk factors (high age, body mass index, systolic blood pressure, triglycerides, smoking, physical inactivity, and low high-density lipoprotein cholesterol), C-reactive protein and 37 cytokines to find the determinants of continuous baseline IR (defined by homeostatic model assessment). A logistic regression model adjusted for the known risk factors, baseline IR, and 37 cytokines was used to predict the future IR.

RESULTS:

Several cytokines, often in a sex-dependent manner, remained as independent determinants of current IR. In men, none of the cytokines was an independent predictive risk marker of future IR. In women, in contrast, IL-17 (odds ratio, 1.42 for 1-SD change in ln-transformed IL-17) and IL-18 (odds ratio, 1.37) were independently associated with the future IR. IL-17 levels also independently predicted the development of incident future IR (odds ratio, 1.48).

CONCLUSIONS:

The systemic levels of the T helper 1 cell cytokine IL-18 and the T helper 17 cell cytokine IL-17 thus may have value in predicting future insulin sensitivity in women independently of classical IR risk factors.

PMID:
27362289
DOI:
10.1210/jc.2016-2081
[Indexed for MEDLINE]

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