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Br J Cancer. 1989 Jun;59(6):865-8.

Interaction of the novel agent amphethinile with tubulin.

Author information

1
Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Manchester, UK.

Abstract

The novel agent amphethinile is shown to inhibit tubulin assembly in vitro. This agent is capable of displacing colchicine but not vinblastine from tubulin and causes a stimulation in GTPase activity in vitro. The affinity constant for the association of this drug with tubulin has been determined (Ka = 1.3 x 10(6) M-1). It is concluded that amphethinile belongs to the class of agents which share a common binding site with colchicine on the tubulin molecule.

PMID:
2736224
PMCID:
PMC2246728
DOI:
10.1038/bjc.1989.183
[Indexed for MEDLINE]
Free PMC Article

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