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J Clin Microbiol. 2016 Sep;54(9):2388-90. doi: 10.1128/JCM.01268-16. Epub 2016 Jun 29.

Multicenter Evaluation of the Solana Group A Streptococcus Assay: Comparison with Culture.

Author information

1
Molecular Pathology, Marshfield Labs, Marshfield, Wisconsin, USA uphoff.timothy@marshfieldclinic.org.
2
Pathology & Laboratory Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
3
Laboratory Alliance of Central New York, Liverpool, New York, USA.
4
Department of Pathology, University of Utah, Salt Lake City, Utah, USA Primary Children's Medical Center, Salt Lake City, Utah, USA.
5
Molecular Pathology, Marshfield Labs, Marshfield, Wisconsin, USA.

Abstract

We compared group A Streptococcus (GAS) culture with a rapid helicase-dependent amplification (HDA) method using 1,082 throat swab specimens. The HDA method demonstrated 98.2% sensitivity and 97.2% specificity. GAS prevalence by culture was 20.7%, and it was 22.6% using the HDA method. In 35 min, the HDA method provided rapid, sensitive GAS detection, making culture confirmation unnecessary.

PMID:
27358464
PMCID:
PMC5005512
DOI:
10.1128/JCM.01268-16
[Indexed for MEDLINE]
Free PMC Article

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