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Chin J Integr Med. 2016 Oct;22(10):795-800. doi: 10.1007/s11655-015-2405-x. Epub 2016 Jun 29.

Pleiotropic effects of herbs characterized with blood-activating and stasis-resolving functions on angiogenesis.

Author information

1
Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
2
Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
3
Department of Pharmacy, Provincial Hospital Affiliated to Anhui Medical University, Hefei, 230001, China.
4
Fujian Provincial Hospital, Clinical College of Fujian Medical University, Fuzhou, 350001, China.
5
Department of Pharmacology, Hanlin College, Nanjing University of Chinese Medicine, Taizhou Jiangsu Province, 225300, China.
6
Department of Pharmaceutics, Jinling Hospital, Nanjing University School of Medicine, Nanjing, 210002, China.
7
Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China. profyinlu@163.com.
8
Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing, 210023, China. profyinlu@163.com.

Abstract

Accumulative evidences have underpinned the nature candidates from Chinese medicine (CM), particularly CM served as blood activating and stasis resolving (BASR, Huoxue Huayu in Chinese) by targeting tumor-associated angiogenesis. However, recent experiment research on the therapeutic angiogenesis by BASR-CM attracts wide attention and discussion. This opinion review focused on the underlying link between two indications and anticipated that (1) BASR-CM might emphasize on a balanced multi-cytokines network interaction; (2) BASR-CM might address on the nature of diseases prior to differently affecting physiological and pathological angiogenesis; (3) BASR-CM might mainly act on perivascular cells, either promotes arteriogenesis by increasing arteriogenic factors in ischemic diseases, or simultaneously keep a quiescent vasculature to impede angiogenesis in tumor context.

KEYWORDS:

Chinese medicine; anti-angiogenesis; arteriogenesis; blood activating and stasis resolving; pathological angiogenesis; physiological angiogenesis; pro-angiogenesis

PMID:
27358204
DOI:
10.1007/s11655-015-2405-x
[Indexed for MEDLINE]

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