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BMC Genomics. 2016 Jun 29;17 Suppl 3:436. doi: 10.1186/s12864-016-2785-0.

Genome-wide association study of prolactin levels in blood plasma and cerebrospinal fluid.

Author information

1
Department of Biology, Brigham Young University, Provo, UT, 84602, USA.
2
Biology and Biomedical Sciences, Washington University, St. Louis, MO, 63110, USA.
3
Department of Neuroscience Icahn School of Medicine, New York, NY, 10029, USA.
4
Department of Biology, Brigham Young University, Provo, UT, 84602, USA. Kauwe@byu.edu.

Abstract

BACKGROUND:

Prolactin is a polypeptide hormone secreted by the anterior pituitary gland that plays an essential role in lactation, tissue growth, and suppressing apoptosis to increase cell survival. Prolactin serves as a key player in many life-critical processes, including immune system and reproduction. Prolactin is also found in multiple fluids throughout the body, including plasma and cerebrospinal fluid (CSF).

METHODS:

In this study, we measured prolactin levels in both plasma and CSF, and performed a genome-wide association study. We then performed meta-analyses using METAL with a significance threshold of p < 5 × 10(-8) and removed SNPs where the direction of the effect was different between the two datasets.

RESULTS:

We identified 12 SNPs associated with increased prolactin levels in both biological fluids.

CONCLUSIONS:

Our efforts will help researchers understand how prolactin is regulated in both CSF and plasma, which could be beneficial in research for the immune system and reproduction.

KEYWORDS:

Association; CSF; Genetics; Plasma; Prolactin

PMID:
27357110
PMCID:
PMC4943503
DOI:
10.1186/s12864-016-2785-0
[Indexed for MEDLINE]
Free PMC Article

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