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Contact Dermatitis. 2016 Nov;75(5):303-307. doi: 10.1111/cod.12623.

A variant of the CXCL11 gene may influence susceptibility to contact allergy, particularly in polysensitized patients.

Author information

1
Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-University Bochum (IPA), Ruhr-University Bochum, 44789, Bochum, Germany. westphal@ipa-dguv.de.
2
Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-University Bochum (IPA), Ruhr-University Bochum, 44789, Bochum, Germany.
3
DRK-Blood Transfusion Service West, Centre for Transfusion Medicine Breitscheid, 40885, Ratingen, Germany.
4
Klinik für Dermatologie, Allergologie und Venerologie Medizinische Hochschule, 30625, Hannover, Germany.
5
Department of Dermatology, Venereology and Allergology, St. Josef-Hospital, Ruhr-University Bochum, 44791, Bochum, Germany.
6
Department of Clinical Social Medicine, Centre of Occupational and Environmental Dermatology, Heidelberg University Hospital, 69115, Heidelberg, Germany.
7
Department of Dermatology, Universitätsklinikum Carl Gustav Carus, 01307, Dresden, Germany.
8
Department of Dermatology, Jena University Hospital, 07743, Jena, Germany.
9
Dermatologikum Hamburg, 20354, Hamburg, Germany.
10
Berufsgenossenschaftliches, Unfallkrankenhaus Hamburg Dermatologie, 21033, Hamburg, Germany.
11
Department of Dermatology and Allergy, Allergy-Center Charite, Universitätsmedizin Berlin, 10117, Berlin, Germany.
12
Department of Dermatology and Allergy, Ludwig Maximilian University, 80337, Munich, Germany.
13
Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, 49090, Osnabrück, Germany.
14
Department of Dermatology, University Hospital Heidelberg, 69120, Heidelberg, Germany.
15
Department of Occupational Dermatology, Berufsgenossenschaftliche-Klinik Falkenstein, 08223, Falkenstein, Germany.
16
Department of Dermatology, Saarland University Medical School, 66424, Homburg, Saar, Germany.
17
Department of Dermatology, Bethesda Hospital, 57258, Freudenberg, Germany.
18
Department of Dermatology and Venereology, Martin Luther University Halle-Wittenberg, 06120, Halle, Saale, Germany.
19
Department of Dermatology, SLK Hospital Heilbronn, 74078, Heilbronn, Germany.
20
Information Network of Departments of Dermatology (IVDK), Georg-August-University Göttingen, 37075, Göttingen, Germany.

Abstract

BACKGROUND:

Hereditary factors may influence individual susceptibility to contact allergy.

OBJECTIVES:

To investigate genetic variants with impacts on early inflammatory reactions and T cell functions that possibly increase the risk of contact allergy.

PATIENTS AND METHODS:

Three hundred and seventy two patients undergoing patch testing were recruited from the Information Network of Departments of Dermatology (IVDK). Of these, 133 were monosensitized and 239 were polysensitized, defined as reacting to three or more unrelated sensitizers. Within the polysensitized individuals, a subgroup with at least one particularly strong patch test reaction (strong reactors; n = 194) was considered. Three hundred and forty-seven blood bank donors served as controls. Fifteen genetic variants in 13 genes were analysed.

RESULTS:

The homozygous variant CXCL11 AA genotype (rs6817952) was significantly more frequent among polysensitized patients (10 of 239 = 4.2%; p = 0.0048; odds ratio 7.49; 95%CI: 1.7-36.1) than among monosensitized patients (2.2%) and in the control group (0.6%). None of the remaining genetic variants investigated were characterized by similarly strong associations. However, the significance was lost after correction for multiple comparisons.

CONCLUSIONS:

The homozygous variant CXCL11 genotype is associated with an increased risk of contact allergy. To confirm this exploratory finding, further independent studies are needed.

KEYWORDS:

CXCL11; contact allergy; polysensitization

PMID:
27356947
DOI:
10.1111/cod.12623
[Indexed for MEDLINE]

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