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Health Phys. 2016 Aug;111(2):198-203. doi: 10.1097/HP.0000000000000459.

Adult Mesenchymal Stem Cells and Radiation Injury.

Author information

1
*Scientific Research Department, Armed Forces Radiobiology Research Institute; Department of Radiation Biology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20889-1076.

Abstract

Recent understanding of the cellular and molecular signaling activations in adult mesenchymal stem cells (MSCs) has provided new insights into their potential clinical applications, particularly for tissue repair and regeneration. This review focuses on these advances, specifically in the context of self-renewal for tissue repair and recovery after radiation injury. Thus far, MSCs have been characterized extensively and shown to be useful in mitigation and therapy for acute radiation syndrome and cognitive dysfunction. Use of MSCs for treating radiation injury alone or in combination with additional trauma is foreseeable.

PMID:
27356065
PMCID:
PMC4929992
DOI:
10.1097/HP.0000000000000459
[Indexed for MEDLINE]
Free PMC Article

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