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Ann Otol Rhinol Laryngol. 2016 Oct;125(10):815-22. doi: 10.1177/0003489416655353. Epub 2016 Jun 28.

Quantitative Evaluation of Adult Subglottic Stenosis Using Intraoperative Long-range Optical Coherence Tomography.

Author information

1
Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine, California, USA.
2
Beckman Laser Institute, University of California, Irvine, California, USA.
3
Beckman Laser Institute, University of California, Irvine, California, USA Department of Biomedical Engineering, University of California, Irvine, California, USA.
4
Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine, California, USA University Voice and Swallowing Center, University of California, Irvine, California, USA verma@uci.edu.

Abstract

OBJECTIVES:

To determine the feasibility of long-range optical coherence tomography (LR-OCT) as a tool to intraoperatively image and measure the subglottis and trachea during suspension microlaryngoscopy before and after endoscopic treatment of subglottic stenosis (SGS).

METHODS:

Long-range optical coherence tomography of the adult subglottis and trachea was performed during suspension microlaryngoscopy before and after endoscopic treatment for SGS. The anteroposterior and transverse diameters, cross-sectional area (CSA), distance from the vocal cords, and length of the SGS were measured using a MATLAB software. Pre-intervention and postintervention airway dimensions were compared. Three-dimensional volumetric airway reconstructions were generated using medical image processing software (MIMICS).

RESULTS:

Intraoperative LR-OCT imaging was performed in 3 patients undergoing endoscopic management of SGS. Statistically significant differences in mean anteroposterior diameter (P < .01), transverse diameter (P < .001), and CSA (P < .001) were noted between pre-intervention and postintervention data. Three-dimensional airway models were viewed in cross-sectional format and via virtual "fly through" bronchoscopy.

CONCLUSIONS:

This is the first report of intraoperative LR-OCT of the subglottic and tracheal airway before and after surgical management of SGS in humans. Long-range optical coherence tomography offers a practical means to measure the dimensions of SGS and acquire objective data on the response to endoscopic treatment of SGS.

KEYWORDS:

airway measurement; direct laryngoscopy; optical coherence tomography; subglottic stenosis; suspension microlaryngoscopy

PMID:
27354215
PMCID:
PMC5127265
DOI:
10.1177/0003489416655353
[Indexed for MEDLINE]
Free PMC Article

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