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Chem Commun (Camb). 2016 Jul 28;52(59):9232-5. doi: 10.1039/c6cc03814j. Epub 2016 Jun 29.

Active tumor-targeting luminescent gold clusters with efficient urinary excretion.

Author information

1
State Key Laboratory of Heavy Oil Processing, China University of Petroleum (East China), Qingdao 266580, China. fhuang@upc.edu.cn.

Abstract

We present novel active targeting luminescent gold nanoclusters (AuNCs), which are prepared through a one-pot procedure by using a pentapeptide (CRGDS) for stabilization and tumor recognition. CRGDS-AuNCs exhibit a high tumor-specific retention with an exceptionally high tumor-to-liver uptake ratio of 9.3. Their small hydrodynamic diameter and zwitterionic surface facilitate urinary excretion, which reaches 82% within 24 h after injection.

PMID:
27354156
DOI:
10.1039/c6cc03814j
[Indexed for MEDLINE]

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