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Enferm Infecc Microbiol Clin. 2017 Nov;35(9):593-602. doi: 10.1016/j.eimc.2016.05.008. Epub 2016 Jun 25.

Microbiological diagnosis of human papilloma virus infection.

[Article in English, Spanish]

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Servicio de Microbiología, Hospital Universitario Ramón y Cajal, Madrid, España. Electronic address:
Servicio de Microbiología, Complejo Hospitalario Universitario de Vigo, Vigo, Pontevedra, España.
Servicio de Microbiología, Hospital Puerta del Mar, Cádiz, España.
Servicio de Microbiología, Facultad de Ciencias de la Salud, Área de Microbiología, Universidad CEU Cardenal Herrera, Moncada, Valencia, España.


Infection with human papillomavirus (HPV) is the leading cause of sexually transmitted infection worldwide. This virus generally causes benign lesions, such as genital warts, but persistent infection may lead to cervical cancer, anal cancer, vaginal cancer, and oropharyngeal cancer, although less frequently. Cervical cancer is a severe disease with a high mortality in some countries. Screening with cytology has been very successful in the last few years, but nowadays there are numerous studies that confirm that cytology should be replaced with the detection of HPV as a first line test in population based screening. There are several commercially available FDA approved tests for screening of cervical cancer. A new strategy, based on individual detection of the high risk genotypes HPV16 and HPV18, present in 70% of cervical cancer biopsies, has been proposed by some experts, and is going to be implemented in most countries in the future.


Cervical cancer; Cribado; Cáncer de cuello de útero; Human papillomavirus; Human papillomavirus DNA test; Human papillomavirus screening; Prueba ADN; Virus del papiloma humano

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