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Trends Microbiol. 2016 Oct;24(10):801-810. doi: 10.1016/j.tim.2016.06.001. Epub 2016 Jun 25.

The Bacterial Microbiome and Virome Milestones of Infant Development.

Author information

1
Departments of Molecular Microbiology and Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
2
Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA. Electronic address: holtz_l@kids.wustl.edu.

Abstract

The human gut harbors a complex community of bacteria, viruses, fungi, protists, and other microorganisms (collectively termed the microbiome) that impact health and disease. Emerging studies indicate that the gut bacterial microbiome and virome play an important role in healthy infant development. In turn, the composition of the microbiome during development can be influenced by factors such as dietary, environmental, and maternal conditions. As such, the microbiome trajectory during early infancy could be predictors of healthy development. Conversely, adverse early events in life may have consequences later in life. This review focuses on our understanding of the bacterial microbiome and virome during early development, conditions that might influence these processes, and their long-term implications for infant health.

KEYWORDS:

infant; microbiome; virome

PMID:
27353648
DOI:
10.1016/j.tim.2016.06.001
[Indexed for MEDLINE]

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