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The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding.
Woodford MR, Dunn DM, Blanden AR, Capriotti D, Loiselle D, Prodromou C, Panaretou B, Hughes PF, Smith A, Ackerman W, Haystead TA, Loh SN, Bourboulia D, Schmidt LS, Marston Linehan W, Bratslavsky G, Mollapour M. Woodford MR, et al. Nat Commun. 2016 Jun 29;7:12037. doi: 10.1038/ncomms12037. Nat Commun. 2016. PMID: 27353360 Free PMC article.
Post-translational Regulation of FNIP1 Creates a Rheostat for the Molecular Chaperone Hsp90.
Sager RA, Woodford MR, Backe SJ, Makedon AM, Baker-Williams AJ, DiGregorio BT, Loiselle DR, Haystead TA, Zachara NE, Prodromou C, Bourboulia D, Schmidt LS, Linehan WM, Bratslavsky G, Mollapour M. Sager RA, et al. Cell Rep. 2019 Jan 29;26(5):1344-1356.e5. doi: 10.1016/j.celrep.2019.01.018. Cell Rep. 2019. PMID: 30699359 Free PMC article.