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Mamm Genome. 2016 Aug;27(7-8):381-95. doi: 10.1007/s00335-016-9651-x. Epub 2016 Jun 28.

Mitophagy plays a central role in mitochondrial ageing.

Author information

1
Nuffield Department of Obstetrics and Gynaecology, The Women's centre, University of Oxford, Oxford, OX3 9DU, UK. alan.diot@obs-gyn.ox.ac.uk.
2
Nuffield Department of Obstetrics and Gynaecology, The Women's centre, University of Oxford, Oxford, OX3 9DU, UK.

Abstract

The mechanisms underlying ageing have been discussed for decades, and advances in molecular and cell biology of the last three decades have accelerated research in this area. Over this period, it has become clear that mitochondrial function, which plays a major role in many cellular pathways from ATP production to nuclear gene expression and epigenetics alterations, declines with age. The emerging concepts suggest novel mechanisms, involving mtDNA quality, mitochondrial dynamics or mitochondrial quality control. In this review, we discuss the impact of mitochondria in the ageing process, the role of mitochondria in reactive oxygen species production, in nuclear gene expression, the accumulation of mtDNA damage and the importance of mitochondrial dynamics and recycling. Declining mitophagy (mitochondrial quality control) may be an important component of human ageing.

PMID:
27352213
PMCID:
PMC4935730
DOI:
10.1007/s00335-016-9651-x
[Indexed for MEDLINE]
Free PMC Article

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