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Nutr Cancer. 2016 Aug-Sep;68(6):968-77. doi: 10.1080/01635581.2016.1190020. Epub 2016 Jun 28.

Breastfeeding, Other Early Life Exposures and Childhood Leukemia and Lymphoma.

Author information

  • 1a School of Public Health , University of Haifa , Haifa , Israel.
  • 2b Exercise, Lifestyle and Nutrition Clinic , The Edmond and Lily Safra Children's Hospital, Sheba Medical Center , Ramat Gan , Israel.
  • 3c Israel Center for Disease Control , Ministry of Health , Ramat Gan , Israel.
  • 4d School of Public Health , Faculty of Social Welfare and Health Sciences, University of Haifa , Haifa , Israel.

Abstract

Childhood cancer incidence increases and although rare, it is a leading cause of mortality. Leukemia and lymphoma comprise 40% of all cancers in children but little is known of their etiology. In this study, we examined the associations of breastfeeding and other early life exposures with childhood leukemia and lymphoma. A population-based case-control study carried out in 2011-2013 comprised mothers of 190 incidents (2005-2013) of leukemia/lymphoma cases aged 1-19 yr at diagnosis and 384 population-based controls. Interviews based on a computerized structured questionnaire were conducted with the mothers. Multivariate logistic regression models adjusted for potential confounders assessed the association between breastfeeding patterns and childhood leukemia/lymphoma. Ever breastfeeding category was associated with a 64% decreased risk for childhood leukemia/lymphoma lsqb;odds ratio (OR) = 0.36, 95% confidence interval (CI): 0.22, 0.60lrqb; and similar trends, with a dose-response effect, were observed for any breastfeeding (exclusive and/or partial) category for 6, 12, and 18+ mo. Other infant exposures associated with cancer risk were child iron supplementation (OR = 0.39, 95% CI: 0.26, 0.59), pet ownership (OR = 0.50, 95% CI: 0.33, 0.78), paternal smoking (OR = 1.93, 95% CI: 1.18, 3.15), and having older siblings (OR = 1.18, 95% CI: 1.05, 1.33). Breastfeeding-a controllable and modifiable exposure-is inversely associated with risk for childhood leukemia and lymphoma with a dose-response effect.

PMID:
27352124
DOI:
10.1080/01635581.2016.1190020
[PubMed - in process]
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