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Biomol NMR Assign. 2016 Oct;10(2):329-33. doi: 10.1007/s12104-016-9694-7. Epub 2016 Jun 28.

(1)H, (13)C, and (15)N resonance assignments for the pro-inflammatory cytokine interleukin-36α.

Author information

1
Leibniz Institute on Aging - Fritz Lipmann Institute, Beutenbergstr. 11, 07745, Jena, Germany.
2
Pharmaceutical Chemistry I, Institute of Pharmacy, University of Bonn, Brühler Str. 7, 53119, Bonn, Germany.
3
Institute of Biochemistry/Biotechnology, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Str. 3, 06120, Halle/Saale, Germany.
4
Leibniz Institute on Aging - Fritz Lipmann Institute, Beutenbergstr. 11, 07745, Jena, Germany. oliver.ohlenschlaeger@leibniz-fli.de.

Abstract

Interleukin-36α (IL-36α) is a recently characterised member of the interleukin-1 superfamily. It is involved in the pathogenesis of inflammatory arthritis in one third of psoriasis patients. By binding of IL-36α to its receptor IL-36R via the NF-κB pathway other cytokines involved in inflammatory and apoptotic cascade are activated. The efficacy of complex formation is controlled by N-terminal processing. To obtain a more detailed view on the structure function relationship we performed a heteronuclear multidimensional NMR investigation and here report the (1)H, (13)C, and (15)N resonance assignments for the backbone and side chain nuclei of the pro-inflammatory cytokine interleukin-36α.

KEYWORDS:

Backbone resonance assignments; Cytokine; Heteronuclear NMR; Interleukin-1 superfamily; Interleukin-36α

PMID:
27351892
DOI:
10.1007/s12104-016-9694-7
[Indexed for MEDLINE]

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