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Fundam Clin Pharmacol. 2016 Dec;30(6):616-624. doi: 10.1111/fcp.12214. Epub 2016 Jul 13.

Overview of drug data within French health insurance databases and implications for pharmacoepidemiological studies.

Palmaro A1,2,3, Moulis G1,2,3,4, Despas F1,2,3, Dupouy J2,5, Lapeyre-Mestre M1,2,3.

Author information

1
Medical and Clinical Pharmacology Unit, CHU Toulouse University Hospital, 37, Allées Jules Guesde, 31000, Toulouse, France.
2
Pharmacoepidemiology Research Unit, INSERM 1027, University of Toulouse, 37, Allées Jules Guesde, 31000, Toulouse, France.
3
CIC 1436, Toulouse University Hospital, Place du Docteur Baylac - TSA 40031, 31059, Toulouse Cedex 9, France.
4
Department of Internal Medicine, Toulouse University Hospital, Place du Docteur Baylac - TSA 40031, 31059, Toulouse Cedex 9, France.
5
Academic Department of Family Medicine, Faculty of Medicine Toulouse, University of Toulouse, 133 route de Narbonne, 31062, Toulouse, France.

Abstract

In this study, we aimed to provide an updated overview of drug data contained in the French health insurance database (SNIIRAM) and its associated national representative sample (EGB). This study identified most common problems concerning drug data: (i) change in level of coverage of drugs of interest (drug no more eligible for reimbursement or no more prescription-only), (ii) break in patients' eligibility (in connection with change of healthcare plan or patients' identifier), and (iii) technical and regulatory issues. We provide a brief checklist to enable a structured identification of these issues. The impact of gap in drug data availability on study validity will depend on the research question, drug, setting, and population of interest. The French health insurance database and associated sample are valuable resources for pharmacoepidemiological research. There is a need to pursue further methodological and validation studies to promote accurate and transparent use of French health insurance databases for pharmacoepidemiology.

KEYWORDS:

SNIIRAM ; France; databases; electronic healthcare records; pharmacoepidemiology

PMID:
27351637
DOI:
10.1111/fcp.12214
[Indexed for MEDLINE]

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