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Ann N Y Acad Sci. 2016 Jun;1374(1):168-75. doi: 10.1111/nyas.13123. Epub 2016 Jun 28.

Macrophages and inflammatory mediators in pulmonary injury induced by mustard vesicants.

Author information

1
Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, New Jersey.
2
Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
3
Department of Environmental Health Science, New York Medical College, Valhalla, New York.
4
Department of Environmental and Occupational Health, School of Public Health, Rutgers University, Piscataway, New Jersey.

Abstract

Sulfur mustard (SM) and nitrogen mustard (NM) are cytotoxic alkylating agents that cause severe and progressive injury to the respiratory tract, resulting in significant morbidity and mortality. Evidence suggests that macrophages and the inflammatory mediators they release play roles in both acute and long-term pulmonary injuries caused by mustards. In this article, we review the pathogenic effects of SM and NM on the respiratory tract and potential inflammatory mechanisms contributing to this activity.

KEYWORDS:

inflammatory mediators; macrophages; mustards; pulmonary toxicity

PMID:
27351588
PMCID:
PMC5119480
DOI:
10.1111/nyas.13123
[Indexed for MEDLINE]
Free PMC Article

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