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J Clin Transl Hepatol. 2016 Jun 28;4(2):97-112. doi: 10.14218/JCTH.2016.00007. Epub 2016 Jun 15.

Interferon-Free Treatments for Chronic Hepatitis C Genotype 1 Infection.

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Department of Pharmacy Practice, University of the Incarnate Word Feik School of Pharmacy, San Antonio, Texas, USA.
University of Texas Health Science Center, San Antonio, Texas, USA.


Hepatitis C virus (HCV) infection affects as many as 185 million people globally, many of whom are chronically infected and progress over time to cirrhosis, decompensated liver disease, hepatocellular carcinoma, and eventually death without a liver transplant. In the United States, HCV genotype 1 constitutes about 75% of all infections. While interferon and ribavirin therapy was the cornerstone of treatment for many years, interferon-free treatments have become the standard of care with the emergence of new direct-acting agents, resulting in more effective treatment, shorter duration of therapy, better tolerability, lower pill burden, and ultimately better adherence. This review will summarize the evidence for the currently available combination therapies as well as emerging therapies in phase 3 trials for treatment of HCV genotype 1.


Direct acting antiretroviral agents; Genotype 1; HCV; Hepatitis C

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