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Mycopathologia. 2016 Oct;181(9-10):753-8. doi: 10.1007/s11046-016-0030-7. Epub 2016 Jun 28.

Cunninghamella bertholletiae Infection in a HLA-Haploidentical Hematopoietic Stem Cell Transplant Recipient with Graft Failure: Case Report and Review of the Literature.

Author information

1
Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, China.
2
Department of Hematology, Jinhua Central Hospital, No. 351 Mingyue Road, Jinhua, 321000, China.
3
Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, China. huanghe@zju.edu.cn.

Abstract

Cunninghamella bertholletiae as a rare cause of mucormycosis has been described almost exclusively in immunosuppressed patients such as hematopoietic stem cell transplant (HSCT) recipients. The infection is associated with high rates of mortality despite aggressive treatment. We describe a 40-year-old male with HLA-haploidentical HSCT developed fungal pneumonitis caused by C. bertholletiae complicated by graft failure and prolonged neutropenia. The patient died 102 days after HSCT despite early use of posaconazole and amphotericin B, which are believed to be the two most effective antifungal antibiotics against C. bertholletiae. The case highlights extreme unfavorable outcome in C. bertholletiae infection and neutropenia as a major risk factor.

KEYWORDS:

Cunninghamella; Fungal pneumonia; Mucormycosis; Stem cell transplantation

PMID:
27350325
DOI:
10.1007/s11046-016-0030-7
[Indexed for MEDLINE]

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