Format

Send to

Choose Destination
See comment in PubMed Commons below
Sci Rep. 2016 Jun 28;6:28616. doi: 10.1038/srep28616.

Prenatal maternal stress and wheeze in children: novel insights into epigenetic regulation.

Author information

  • 1Department of Environmental Immunology, Helmholtz Centre for Environmental Research Leipzig-UFZ, Permoserstraße 15, Leipzig, 04318, Germany.
  • 2Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany.
  • 3Heidelberg Center for Personalized Oncology, DKFZ-HIPO, DKFZ, Im Neuenheimer Feld 267, Heidelberg, 69120, Germany.
  • 4Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • 5Municipal Hospital "St. Georg" Children's Hospital, Delitzscher Straße 141, 04129 Leipzig, Germany.
  • 6Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany.
  • 7Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany.
  • 8Division of Endocrinology and Nephrology, University of Leipzig, Liebigstraße 21, Leipzig, 04103, Germany.
  • 9Department of Urban and Environmental Sociology, Helmholtz Centre for Environmental Research Leipzig-UFZ, Permoserstraße 15, Leipzig, 04318, Germany.
  • 10Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research-UFZ, 04318, Leipzig, Germany.
  • 11Faculty of Biosciences, Pharmacy, and Psychology, University of Leipzig, 04318, Leipzig, Germany.
  • 12Department of Chemistry and Biosciences, Aalborg University, DK-9220 Aalborg, Denmark.
  • 13Institute of Pharmacy and Molecular Biotechnology, and Bioquant Center, University of Heidelberg, Im Neuenheimer Feld 267, Heidelberg, 69120, Germany.
  • 14Department of Pediatrics, Kravis Children's Hospital, Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • 15Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), University of Heidelberg, 69120, Germany.

Abstract

Psychological stress during pregnancy increases the risk of childhood wheeze and asthma. However, the transmitting mechanisms remain largely unknown. Since epigenetic alterations have emerged as a link between perturbations in the prenatal environment and an increased disease risk we used whole genome bisulfite sequencing (WGBS) to analyze changes in DNA methylation in mothers and their children related to prenatal psychosocial stress and assessed its role in the development of wheeze in the child. We evaluated genomic regions altered in their methylation level due to maternal stress based of WGBS data of 10 mother-child-pairs. These data were complemented by longitudinal targeted methylation and transcriptional analyses in children from our prospective mother-child cohort LINA for whom maternal stress and wheezing information was available (n = 443). High maternal stress was associated with an increased risk for persistent wheezing in the child until the age of 5. Both mothers and children showed genome-wide alterations in DNA-methylation specifically in enhancer elements. Deregulated neuroendocrine and neurotransmitter receptor interactions were observed in stressed mothers and their children. In children but not in mothers, calcium- and Wnt-signaling required for lung maturation in the prenatal period were epigenetically deregulated and could be linked with wheezing later in children's life.

PMID:
27349968
PMCID:
PMC4923849
DOI:
10.1038/srep28616
[PubMed - in process]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Support Center