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FEBS Lett. 2016 Aug;590(16):2584-93. doi: 10.1002/1873-3468.12271. Epub 2016 Jul 14.

Changes in expression of C2cd4c in pancreatic endocrine cells during pancreatic development.

Author information

  • 1Institute of Molecular Embryology and Genetics, Kumamoto University, Japan.
  • 2Department of Life Science and Technology, School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan.
  • 3Division of Pharmacology, National Institute of Health Science, Kamiyoga, Setagaya-ku, Tokyo, Japan.
  • 4HIGO program, Kumamoto University, Japan.
  • 5Division of Developmental Genetics, Institute of Resource Development and Analysis, Kumamoto University, Japan.
  • 6Division of Reproductive Engineering, Institute of Resource Development and Analysis, Kumamoto University, Japan.


C2cd4c, encoded by a gene belonging to the C2cd4 family, contains a C2 domain conserved across species and is localized to the cytoplasm. To examine the role of C2cd4c in the pancreas, we studied its localization and generated C2cd4c knockout (KO) mice. C2cd4c was expressed in pancreatic endocrine progenitors at early embryonic stages. When endocrine cells arise from their precursors, C2cd4c is gradually confined to the insulin- and pancreatic polypeptide-expressing cells of the endocrine. In the adult pancreas, C2cd4c is restricted to the beta cells. C2cd4c KO mice showed normal embryonic pancreatic development and adult pancreatic function. Thus, our results suggest that C2cd4c is dispensable for pancreatic development.


C2cd4; insulin; pancreas; pancreatic beta cell

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