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Cell Res. 2016 Aug;26(8):867-8. doi: 10.1038/cr.2016.82. Epub 2016 Jun 28.

Microenvironmental InterFereNce of metabolism regulates chemosensitivity.

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Ludwig Institute for Cancer Research, Lausanne, Switzerland.
Department of Oncology, University of Lausanne, Lausanne, Switzerland.


The tumor microenvironment is recognized as a critical regulator of cancer progression, and multiple roles are also emerging for the microenvironment in modulating response to therapeutic intervention. A recent study by Wang and colleagues identified IFN-γ as a central effector of CD8 T cell-mediated regulation of glutathione and cysteine metabolism in fibroblasts, which consequently abrogates stromal-induced resistance through modulation of cisplatin intracellular content in ovarian cancer cells.

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