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Am J Transl Res. 2016 May 15;8(5):1998-2010. eCollection 2016.

Clinic significance of markedly decreased α-klothoin women with preeclampsia.

Author information

1
Department of Obstetrics and Gynecology, Renmin Hospital, Wuhan University Hubei, 430060, China.
2
Department of Nutrition and Food Hygiene, School of Public Health, Wuhan University 185, Donghu Rd, Wuhan, Hubei, 430071, China.

Abstract

Preeclampsia (PE) is a leading cause of maternal and perinatal morbidity and mortality. Klotho is a novel gene and the secret form, α-klotho (α-KL), is related to preeclampsia. We conducted this cross-sectional study in Wuhan, China. We used immunohistochemistry, real-time PCR, western blot, ELISA to measure α-KL expression in placenta and its secretion in maternal and umbilical cord serum, and analyzed correlations between α-KL level and other parameters in normal and preeclampsia pregnancy. We found that both mRNA and protein expression of placental α-KL in women with PE was significantly lower than that in normal pregnancy. Also, expression level of α-KL in both maternal and umbilical cord was markedly decreased in PE patients. Further analyses showed that serum α-KL exhibited positive association with fetal birth weight, and reverse association with oxidative stress and renal function markers. Receiver operating characteristic analysis suggested α-KL might be a potential predictor for preeclampsia.

KEYWORDS:

Preeclampsia; fetal birth weight; oxidative stress; receiver operating characteristic; renal function; α-klotho

PMID:
27347309
PMCID:
PMC4891414

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