Send to

Choose Destination
Am J Transl Res. 2016 May 15;8(5):1998-2010. eCollection 2016.

Clinic significance of markedly decreased α-klothoin women with preeclampsia.

Author information

Department of Obstetrics and Gynecology, Renmin Hospital, Wuhan University Hubei, 430060, China.
Department of Nutrition and Food Hygiene, School of Public Health, Wuhan University 185, Donghu Rd, Wuhan, Hubei, 430071, China.


Preeclampsia (PE) is a leading cause of maternal and perinatal morbidity and mortality. Klotho is a novel gene and the secret form, α-klotho (α-KL), is related to preeclampsia. We conducted this cross-sectional study in Wuhan, China. We used immunohistochemistry, real-time PCR, western blot, ELISA to measure α-KL expression in placenta and its secretion in maternal and umbilical cord serum, and analyzed correlations between α-KL level and other parameters in normal and preeclampsia pregnancy. We found that both mRNA and protein expression of placental α-KL in women with PE was significantly lower than that in normal pregnancy. Also, expression level of α-KL in both maternal and umbilical cord was markedly decreased in PE patients. Further analyses showed that serum α-KL exhibited positive association with fetal birth weight, and reverse association with oxidative stress and renal function markers. Receiver operating characteristic analysis suggested α-KL might be a potential predictor for preeclampsia.


Preeclampsia; fetal birth weight; oxidative stress; receiver operating characteristic; renal function; α-klotho


Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center